![]() “Taurine abundance goes down with age, so restoring taurine to a youthful level in old age may be a promising anti-aging strategy.”įor more on this research, see Study Finds Taurine Supplement Improves Health and Longevity. “And it has some advantages: Taurine is naturally produced in our bodies, it can be obtained naturally in the diet, it has no known toxic effects (although it’s rarely used in concentrations used ), and it can be boosted by exercise. “I think taurine should also be considered,” Yadav says. Other potential anti-aging drugs-including metformin, rapamycin, and NAD analogs-are being considered for testing in clinical trials. Taurine trials are currently underway for obesity, but none are designed to measure a wide range of health parameters. Only a randomized clinical trial in people will determine if taurine truly has health benefits, Yadav adds. “No matter the individual, all had increased taurine levels after exercise, which suggests that some of the health benefits of exercise may come from an increase in taurine,” Yadav says. The researchers measured taurine levels before and after a variety of male athletes and sedentary individuals finished a strenuous cycling workout and found a significant increase in taurine among all groups of athletes (sprinters, endurance runners, and natural bodybuilders) and sedentary individuals. The second study tested if taurine levels would respond to an intervention known to improve health: exercise. ![]() “These are associations, which do not establish causation,” Yadav says, “but the results are consistent with the possibility that taurine deficiency contributes to human aging.” Overall, people with higher taurine levels were healthier, with fewer cases of type 2 diabetes, lower obesity levels, reduced hypertension, and lower levels of inflammation. In the first, Yadav and his team looked at the relationship between taurine levels and approximately 50 health parameters in 12,000 European adults aged 60 and over. The researchers do not know yet if taurine supplements will improve health or increase longevity in humans, but two experiments they conducted suggest taurine has potential. Credit: Columbia University Irving Medical Center Randomized clinical trial needed “Not only did we find that the animals lived longer, we also found that they’re living healthier lives,” Yadav says.Ī bout of exercise increases taurine levels. The researchers found that taurine suppressed age-associated weight gain in female mice (even in “menopausal” mice), increased energy expenditure, increased bone mass, improved muscle endurance and strength, reduced depression-like and anxious behaviors, reduced insulin resistance, and promoted a younger-looking immune system, among other benefits. These experts measured various health parameters in mice and found that at age 2 (60 in human years), animals supplemented with taurine for one year were healthier in almost every way than their untreated counterparts. To learn how taurine impacted health, Yadav brought in other aging researchers who investigated the effect of taurine supplementation on the health and lifespan in several species. Credit: Columbia University Irving Medical Center Taurine supplements in middle age improve health in old age For the mice, that meant three to four extra months, equivalent to about seven or eight human years. At the end of the experiment, Yadav and his team found that taurine increased average lifespan by 12% in female mice and 10% in males. Every day, the researcher fed half of them a bolus of taurine or a control solution. The researchers started with close to 250 14-month-old female and male mice (about 45 years old in people terms). “That’s when we started to ask if taurine deficiency is a driver of the aging process, and we set up a large experiment with mice,” Yadav says. In people, taurine levels in 60-year-old individuals were only about one-third of those found in 5-year-olds. Credit: Columbia University Irving Medical Center Taurine declines with age, supplementation increases lifespan in miceįirst, Yadav’s team looked at levels of taurine in the bloodstream of mice, monkeys, and people and found that the taurine abundance decreases substantially with age. Taurine supplementation makes animals healthier and live longer.
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